Can Implementation of Genetics and Pharmacogenomics Improve Treatment of Chronic Low Back Pain?

ABSTRACT: Etiology of back pain is multifactorial and not completely understood, and for the majority of people who suffer from chronic low back pain (cLBP), the precise cause cannot be determined. We know that back pain is somewhat heritable, chronic pain more so than acute. The aim of this review is to compile the genes identified by numerous genetic association studies of chronic pain conditions, focusing on cLBP specifically. Higher-order neurologic processes involved in pain maintenance and generation may explain genetic contributions and functional predisposition to formation of cLBP that does not involve spine pathology. Several genes have been identified in genetic association studies of cLBP and roughly, these genes could be grouped into several categories, coding for: receptors, enzymes, c

SUBMITTER: Suntsov V 

PROVIDER: S-EPMC7558486 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature