S. aureus Colonization, Biofilm Production, and Phage Susceptibility in Peritoneal Dialysis Patients.

ABSTRACT: Peritonitis caused by Staphylococcusaureus is of major importance in peritoneal dialysis (PD) patients due to its great virulence profile and biofilm formation ability. Bacteriophages are a potential tool to treat peritonitis resulting from biofilm-associated infections. We screened S. aureus colonization in 71 PD patients from the nasal cavity, groin, and PD exit-site regions and analyzed clinical outcomes in these patients. We performed biofilm-formation testing of different strains and compared the isolates of one patient to detect phenotypic differences in S. aureus. Phage cocktails were used to detect S. aureus in vitro susceptibility. An adaptation procedure was performed in cases of bacterial resistance. Around 30% of PD patients (n = 21) were found to be S. aureus carriers; from th

SUBMITTER: Racenis K 

PROVIDER: S-EPMC7558627 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature