Spin-lock imaging of intrinsic susceptibility gradients in tumors.

ABSTRACT:

Purpose

Previous studies have shown that diffusion of water through intrinsic susceptibility gradients produces a dispersion of the spin-lattice relaxation rate in the rotating frame (R_{1 ρ} ) over a low range of spin-locking amplitudes (0 < ω₁ < 100 Hz), whereas at higher ω₁ and high magnetic fields, a second dispersion arises due to chemical exchange. Here, we separated these different effects and evaluated their contributions in tumors.

Methods

Maps of R_{1 ρ} and its changes with locking field were acquired on intracranial 9-L tumor models. The R_{1 ρ} changes due to diffusion ( R1ρDiff ) were calculated by subtracting maps of R_{1 ρ} at 100 Hz (R_{1 ρ} [

SUBMITTER: Zu Z 

PROVIDER: S-EPMC7558740 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature