The influences of DNA methylation and epigenetic clocks, on metabolic disease, in middle-aged Koreans.

ABSTRACT:

Background

Considering that DNA methylation (DNAm) profiles are, in large part, modifiable by lifestyle and environmental influences, it has been proposed that epigenetic clocks provide a better estimate of biological age than chronological age, as associated with current health status. Even though metabolic diseases induce precocious aging, little is known about associations between metabolic syndrome (MetS) and DNA methylation clocks, and stochastic epigenetic mutations (SEMs), in a Korean population. Therefore, we assessed four different epigenetic clocks (Pan-tissue, Hannum, PhenoAge, and GrimAge), and their accelerations, on MetS and MetS-related lifestyle factors, in Koreans. We measured genome-wide DNA methylation (485,512 CpGs), using an Illumina 450 methylation BeadChip ar

SUBMITTER: Lee HS 

PROVIDER: S-EPMC7558749 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature