GDF9 polymorphisms: influence on ovarian response in women undergoing controlled ovarian hyperstimulation.

ABSTRACT:

Objective

The study looked into the possible influence of GDF9 polymorphisms on ovarian response in women with a normal ovarian reserve undergoing controlled ovarian hyperstimulation for in vitro fertilization (IVF).

Methods

This cross-sectional study included 67 women with normal ovarian reserve aged 30-39 years submitted to controlled ovarian hyperstimulation for IVF. We sequenced four polymorphisms in the GDF9 gene (C398G, C447T, G546A, and G646A) and analyzed their influence on follicular and oocyte outcomes.

Results

The mutant allele C398G decreased the total number of follicles >17mm (6.49 vs. 4.33, p=0.001), total number of follicles (10.11 vs. 7.33, p=0.032), number of MII oocytes retrieved, and serum progesterone levels on trigger day. The C447T polymorphism

SUBMITTER: Bilibio JP 

PROVIDER: S-EPMC7558902 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature