Natural Products: A Potential Source of Malaria Transmission Blocking Drugs?

ABSTRACT: The ability to block human-to-mosquito and mosquito-to-human transmission of Plasmodium parasites is fundamental to accomplish the ambitious goal of malaria elimination. The WHO currently recommends only primaquine as a transmission-blocking drug but its use is severely restricted by toxicity in some populations. New, safe and clinically effective transmission-blocking drugs therefore need to be discovered. While natural products have been extensively investigated for the development of chemotherapeutic antimalarial agents, their potential use as transmission-blocking drugs is comparatively poorly explored. Here, we provide a comprehensive summary of the activities of natural products (and their derivatives) of plant and microbial origins against sexual stages of Plasmodium parasites and t

SUBMITTER: Moyo P 

PROVIDER: S-EPMC7558993 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature