Trial of remote ischaemic preconditioning in vascular cognitive impairment (TRIC-VCI): protocol.

ABSTRACT:

Introduction

Cerebral small vessel disease (cSVD) accounts for 20%-25% of strokes and is the most common cause of vascular cognitive impairment (VCI). In an animal VCI model, inducing brief periods of limb ischaemia-reperfusion reduces subsequent ischaemic brain injury with remote and local protective effects, with hindlimb remote ischaemic conditioning (RIC) improving cerebral blood flow, decreasing white-matter injury and improving cognition. Small human trials suggest RIC is safe and may prevent recurrent strokes. It remains unclear what doses of chronic daily RIC are tolerable and safe, whether effects persist after treatment cessation, and what parameters are optimal for treatment response.

Methods and analysis

This prospective, open-label, randomised controlled trial (

SUBMITTER: Ganesh A 

PROVIDER: S-EPMC7559076 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature