Association of Leptin Gene Polymorphisms with Rheumatoid Arthritis in a Chinese Population.

ABSTRACT:

Background

Recently, increasing studies have revealed that leptin is involved in the development of rheumatoid arthritis (RA). This study is aimed at exploring the association of leptin gene single nucleotide polymorphisms (SNPs) with susceptibility to RA in a Chinese population.

Methods

We recruited 600 RA patients and 600 healthy controls from a Chinese population and analyzed their three leptin SNPs (rs10244329, rs2071045, and rs2167270) using the improved Multiplex Ligase Detection Reaction (iMLDR) assays. The associations of these SNPs with clinical manifestations of RA were also analyzed. Enzyme-linked immunosorbent assay (ELISA) was performed for plasma leptin determination.

Results

No significant difference in either allele or genotype fre

SUBMITTER: Tao SS 

PROVIDER: S-EPMC7559230 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature