Changes in circulating miRNA19a-3p precede insulin resistance programmed by intra-uterine growth retardation in mice.

ABSTRACT:

Objective

Individuals born with intrauterine growth retardation (IUGR) are more prone to cardio-metabolic diseases as adults, and environmental changes during the perinatal period have been identified as potentially crucial factors. We have studied in a preclinical model early-onset molecular alterations present before the development of a clinical phenotype.

Methods

We used a preclinical mouse model of induced IUGR, in which we modulated the nutrition of the pups during the suckling period, to modify their susceptibility to cardio-metabolic diseases in adulthood.

Results

Mice born with IUGR that were overfed (IUGR-O) during lactation rapidly developed obesity, hepatic steatosis and insulin resistance, by three months of age, whereas those subjected to nutrition restr

SUBMITTER: Saget S 

PROVIDER: S-EPMC7559280 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature