Bioinformatic gene analysis for potential therapeutic targets of Huntington's disease in pre-symptomatic and symptomatic stage.

ABSTRACT:

Background

Huntington's disease (HD) is a neurodegenerative disorder characterized by psychiatric symptoms, serious motor and cognitive deficits. Certain pathological changes can already be observed in pre-symptomatic HD (pre-HD) patients; however, the underlying molecular pathogenesis is still uncertain and no effective treatments are available until now. Here, we reanalyzed HD-related differentially expressed genes from the GEO database between symptomatic HD patients, pre-HD individuals, and healthy controls using bioinformatics analysis, hoping to get more insight in the pathogenesis of both pre-HD and HD, and shed a light in the potential therapeutic targets of the disease.

Methods

Pre-HD and symptomatic HD differentially expressed genes (DEGs) were screened by bioinfor

SUBMITTER: Xiang C 

PROVIDER: S-EPMC7559361 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature