SmORFunction: a tool for predicting functions of small open reading frames and microproteins.

ABSTRACT:

Background

Small open reading frame (smORF) is open reading frame with a length of less than 100 codons. Microproteins, translated from smORFs, have been found to participate in a variety of biological processes such as muscle formation and contraction, cell proliferation, and immune activation. Although previous studies have collected and annotated a large abundance of smORFs, functions of the vast majority of smORFs are still unknown. It is thus increasingly important to develop computational methods to annotate the functions of these smORFs.

Results

In this study, we collected 617,462 unique smORFs from three studies. The expression of smORF RNAs was estimated by reannotated microarray probes. Using a speed-optimized correlation algorism, the functions of smORFs were pred

SUBMITTER: Ji X 

PROVIDER: S-EPMC7559452 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature