Identification of Key Genes Involved in Acute Myocardial Infarction by Comparative Transcriptome Analysis.

ABSTRACT:

Background

Acute myocardial infarction (AMI) is regarded as an urgent clinical entity, and identification of differentially expressed genes, lncRNAs, and altered pathways shall provide new insight into the molecular mechanisms behind AMI.

Materials and methods

Microarray data was collected to identify key genes and lncRNAs involved in AMI pathogenesis. The differential expression analysis and gene set enrichment analysis (GSEA) were employed to identify the upregulated and downregulated genes and pathways in AMI. The protein-protein interaction network and protein-RNA interaction analysis were utilized to reveal key long noncoding RNAs.

Results

In the present study, we utilized gene expression profiles of circulating endothelial cells (CEC) from 49 patients of AMI and

SUBMITTER: Sheng X 

PROVIDER: S-EPMC7559508 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature