Neonatal Lead (Pb) Exposure and DNA Methylation Profiles in Dried Bloodspots.

ABSTRACT: Lead (Pb) exposure remains a major concern in the United States (US) and around the world, even following the removal of Pb from gasoline and other products. Environmental Pb exposures from aging infrastructure and housing stock are of particular concern to pregnant women, children, and other vulnerable populations. Exposures during sensitive periods of development are known to influence epigenetic modifications which are thought to be one mechanism of the Developmental Origins of Health and Disease (DOHaD) paradigm. To gain insights into early life Pb exposure-induced health risks, we leveraged neonatal dried bloodspots in a cohort of children from Michigan, US to examine associations between blood Pb levels and concomitant DNA methylation profiles (n = 96). DNA methylation analysi

SUBMITTER: Montrose L 

PROVIDER: S-EPMC7559513 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature