Rapidly (and Successfully) Translating Novel Brain Radiotracers From Animal Research Into Clinical Use.

ABSTRACT: The advent of preclinical research scanners for in vivo imaging of small animals has added confidence into the multi-step decision-making process of radiotracer discovery and development. Furthermore, it has expanded the utility of imaging techniques available to dissect clinical questions, fostering a cyclic interaction between the clinical and the preclinical worlds. Significant efforts from medicinal chemistry have also made available several high-affinity and selective compounds amenable for radiolabeling, that target different receptors, transporters and enzymes in vivo. This substantially increased the range of applications of molecular imaging using positron emission tomography (PET) or single photon emission computed tomography (SPECT). However, the process of develop

SUBMITTER: Shaw RC 

PROVIDER: S-EPMC7559529 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature