Pharmacokinetic Comparison of Three Different Administration Routes for Topotecan Hydrochloride in Rats.

ABSTRACT: Topotecan is actively used in clinic, with its primary use being in treatment of various types of cancer. The approved administration routes are oral and intravenous. The purpose of this study was to investigate and identify pharmacokinetic profiles of different administration routes. We conducted pharmacokinetic studies on three different routes of administration in rats. Five rats in each group received a single dose of 4 mg/kg of topotecan hydrochloride intravenously, orally, or subcutaneously, and the concentrations of lactone and total forms of the drug in plasma, urine, and feces were quantified. Various pharmacokinetic parameters were compared statistically. Plasma concentrations of both the lactone and total forms at elimination phase following subcutaneous administration, were two

SUBMITTER: Jeong SH 

PROVIDER: S-EPMC7559546 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature