Interaction of Catechol-O-methyltransferase Val¹⁵⁸ Met polymorphism and sex influences association of parietal intrinsic functional connectivity and immediate verbal memory.

ABSTRACT:

Introduction

Sex differences modulate catechol-O-methyltransferase (COMT) genotype effect at a synaptic dopamine level, which influences brain function as well as cognitive performance. In this study, we investigated how COMT Val¹⁵⁸ Met polymorphism and sex affect intrinsic functional connectivity and memory.

Methods

Intrinsic functional networks were extracted using independent component analysis of resting-state functional magnetic resonance imaging data from 186 healthy young COMT-genotyped participants. The association of these functional networks and memory function was tested to investigate whether the effect of COMT × sex interaction influences the association of intrinsic functional connectivity and memory performance. Quadratic curve fit estimation was us

SUBMITTER: Wu S 

PROVIDER: S-EPMC7559624 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature