FMRI activation to cannabis odor cues is altered in individuals at risk for a cannabis use disorder.

ABSTRACT:

Introduction

The smell of cannabis is a cue with universal relevance to cannabis users. However, most cue reactivity imaging studies have solely utilized visual images, auditory imagery scripts, or tactile cues in their experiments. This study introduces a multimodal cue reactivity paradigm that includes picture, odor, and bimodal picture + odor cues.

Methods

Twenty-eight adults at risk for cannabis use disorder (CUD; defined as at least weekly use and Substance Involvement Score of ≥4 on the Cannabis sub-test of the Alcohol, Smoking and Substance Involvement Screening Test) and 26 cannabis-naive controls were exposed to cannabis and floral cues during event-related fMRI. Between-group differences in fMRI activation and correlations were tested using FMRIB's Local Analyses o

SUBMITTER: Kleinhans NM 

PROVIDER: S-EPMC7559640 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature