Impact of mTOR gene polymorphisms and gene-tea interaction on susceptibility to tuberculosis.

ABSTRACT:

Background

mTOR gene is a key component of the PI3K/Akt/mTOR signaling pathway, and its dysregulation is associated with various diseases. Several studies have demonstrated that tea drinking is a protective factor against tuberculosis (TB). This study was designed to explore five single nucleotide polymorphisms (SNPs) of mTOR in the Han population of China to determine how their interactions with tea drinking affect susceptibility to TB.

Aim

To investigate if the polymorphisms of mTOR gene and the gene-tea interaction are associated with susceptibility to TB.

Methods

In this case-control study, 503 patients with TB and 494 healthy controls were enrolled by a stratified sampling method. The cases were newly registered TB patients from the county-le

SUBMITTER: Wang M 

PROVIDER: S-EPMC7559685 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature