Association between childhood trauma and risk for obesity: a putative neurocognitive developmental pathway.

ABSTRACT:

Background

Childhood trauma increases the risk for adult obesity through multiple complex pathways, and the neural substrates are yet to be determined.

Methods

Participants from three population-based neuroimaging cohorts, including the IMAGEN cohort, the UK Biobank (UKB), and the Human Connectome Project (HCP), were recruited. Voxel-based morphometry analysis of both childhood trauma and body mass index (BMI) was performed in the longitudinal IMAGEN cohort; validation of the findings was performed in the UKB. White-matter connectivity analysis was conducted to study the structural connectivity between the identified brain region and subdivisions of the hypothalamus in the HCP.

Results

In IMAGEN, a smaller frontopolar cortex (FPC) was associated with both childhood ab

SUBMITTER: Luo Q 

PROVIDER: S-EPMC7559717 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature