Psoriasis Is Associated With Elevated Gut IL-1α and Intestinal Microbiome Alterations.

ABSTRACT:

Background

Psoriasis is a chronic inflammatory condition that predominantly affects the skin and is associated with extracutaneous disorders, such as inflammatory bowel disease and arthritis. Changes in gut immunology and microbiota are important drivers of proinflammatory disorders and could play a role in the pathogenesis of psoriasis. Therefore, we explored whether psoriasis in a Central Asian cohort is associated with alterations in select immunological markers and/or microbiota of the gut.

Methods

We undertook a case-control study of stool samples collected from outpatients, aged 30-45 years, of a dermatology clinic in Kazakhstan presenting with plaque, guttate, or palmoplantar psoriasis (n = 20), and age-sex matched subjects without psoriasis (n = 20). St

SUBMITTER: Yegorov S 

PROVIDER: S-EPMC7559734 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature