Development of Theranostic Cationic Liposomes Designed for Image-Guided Delivery of Nucleic Acid.

ABSTRACT: Cationic liposomes have been considered as potential vectors for gene delivery thanks to their ability to transfect cells with high efficiency. Recently, the combination of diagnostic agent and therapeutic agents in the same particle to form a theranostic system has been reported. Magnetic liposomes are one of these examples. Due to the magnetic nanoparticles encapsulated in the liposomes, they can act as a drug delivery system and, at the same time, a magnetic resonance imaging contrast enhancement agent or hyperthermia. In this work, nucleic acid delivery systems based on magnetic cationic liposomes (MCLs) were developed. Two different techniques, reverse phase evaporation and cosolvent sonication, were employed for liposome preparation. Both strategies produced MCLs of less than 200 nm

SUBMITTER: Do HD 

PROVIDER: S-EPMC7559777 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature