Cancer stem cell secretome in the tumor microenvironment: a key point for an effective personalized cancer treatment.

ABSTRACT: Cancer stem cells (CSCs) represent a tumor subpopulation responsible for tumor metastasis and resistance to chemo- and radiotherapy, ultimately leading to tumor relapse. As a consequence, the detection and eradication of this cell subpopulation represent a current challenge in oncology medicine. CSC phenotype is dependent on the tumor microenvironment (TME), which involves stem and differentiated tumor cells, as well as different cell types, such as mesenchymal stem cells, endothelial cells, fibroblasts and cells of the immune system, in addition to the extracellular matrix (ECM), different in composition to the ECM in healthy tissues. CSCs regulate multiple cancer hallmarks through the interaction with cells and ECM in their environment by secreting extracellular vesicles including exosom

SUBMITTER: Lopez de Andres J 

PROVIDER: S-EPMC7559894 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature