Flavonoids as Potential anti-MRSA Agents through Modulation of PBP2a: A Computational and Experimental Study.

ABSTRACT: Recently, the interest in plant-derived antimicrobial agents has increased. However, there are no sufficient studies dealing with their modes of action. Herein, we investigate an in-house library of common plant-based phenolic compounds for their potential antibacterial effects against the methicillin-resistant Staphylococcus aureus (MRSA), a widespread life-threatening superbug. Flavonoids, which are considered major constituents in the plant kingdom, were found to be a promising class of compounds against MRSA, particularly the non-glycosylated ones. On the other hand, the glycosylated derivatives, along with the flavonolignan silibinin A, were able to restore the inhibitory activity of ampicillin against MRSA. To explore the mode of action of this class, they were subjected to an

SUBMITTER: Alhadrami HA 

PROVIDER: S-EPMC7559925 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature