Systemic profile of immune factors in an elderly Italian population affected by chronic strongyloidiasis.

ABSTRACT:

Background

Strongyloidiasis caused by Strongyloides stercoralis is a soil-transmitted helminthiasis affecting an estimated 370 million people and considered one of the most neglected tropical diseases. Although mostly distributed in tropical and subtropical areas, autochthonous infections have also been documented in north-eastern Italy, even though the transmission presumably stopped decades ago. Because of its peculiar auto-infective cycle, strongyloidiasis can persist lifelong, but the pathophysiological mechanisms associated with the maintenance of such a chronic infection are yet to be fully deciphered.

Methods

Serum levels of 23 immune factors were retrospectively assessed in a subgroup of participants in a randomised clinical trial for the treatment of strongyloidiasi

SUBMITTER: Tiberti N 

PROVIDER: S-EPMC7559927 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature