Effect of Flavonoid Supplementation on Alveolar Bone Healing-A Randomized Pilot Trial.

ABSTRACT: We investigated the effects of two common dietary supplements on bone healing in dental extraction sockets in humans. In this randomized pilot trial, male subjects took Grape Seed Extract [GSE] or Grapefruit Extract [GFE] starting two weeks prior to dental extraction and maintained this regimen for sixty days after surgery. Extraction sockets were filled with a collagen plug. After 24 h, a socket sample was collected and processed for quantitative real-time reverse transcription polymerase chain reaction (qRT-PCR) and an 84-gene wound healing assay. Sixty days after tooth extraction, a core of newly formed bone was obtained prior to dental implant placement and processed for histology. qRT-PCR revealed that GFE led to a significant decrease in platelet-derived growth factor and interleukin

SUBMITTER: Souza JM 

PROVIDER: S-EPMC7560062 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature