Hepatic FTO is dispensable for the regulation of metabolism but counteracts HCC development in vivo.

ABSTRACT:

Objective

Single-nucleotide polymorphisms in the FTO gene encoding an m⁶Am and an m⁶A demethylase are associated with obesity. Moreover, recent studies have linked a dysregulation of m⁶A modifications and its machinery, including FTO, to the development of several forms of cancers. However, the functional role of hepatic FTO in metabolism and the development and progression of hepatocellular carcinoma (HCC), a proteotypic obesity-associated cancer, remains unclear. Thus, we aimed to reveal the role of hepatic FTO in metabolism and in the initiation and progression of HCC in vivo.

Methods

We generated mice with hepatic FTO deficiency (FTO^L-KO). The effect of hepatic FTO on metabolism was investigated by extensive metabolic phenotypi

SUBMITTER: Mittenbuhler MJ 

PROVIDER: S-EPMC7560164 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature