Use of ICD-10 diagnosis codes to identify seropositive and seronegative rheumatoid arthritis when lab results are not available.

ABSTRACT:

Background

Rheumatoid factor (RF) and anti-cyclic citrullinated peptide (CCP) antibody tests are often measured at the time of rheumatoid arthritis (RA) diagnosis but may not be repeated and therefore not available in electronic health record (EHR) data; lab test results are unavailable in most administrative claims databases. ICD10 coding allows discrimination between rheumatoid factor positive (M05) ("seropositive") and seronegative (M06) patients, but the validity of these codes has not been examined.

Methods

Using the ACR's Rheumatology Informatics System for Effectiveness (RISE) EHR-based registry and U.S. MarketScan data where some patients have lab test results, we assembled two cohorts. Seropositive RA was defined having a M05 diagnosis code on the second rheumatolog

SUBMITTER: Curtis JR 

PROVIDER: S-EPMC7560310 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature