Mutations of SARS-CoV-2 nsp14 exhibit strong association with increased genome-wide mutation load.

ABSTRACT: SARS-CoV-2 is a betacoronavirus responsible for COVID-19, a pandemic with global impact that first emerged in late 2019. Since then, the viral genome has shown considerable variance as the disease spread across the world, in part due to the zoonotic origins of the virus and the human host adaptation process. As a virus with an RNA genome that codes for its own genomic replication proteins, mutations in these proteins can significantly impact the variance rate of the genome, affecting both the survival and infection rate of the virus, and attempts at combating the disease. In this study, we analyzed the mutation densities of viral isolates carrying frequently observed mutations for four proteins in the RNA synthesis complex over time in comparison to wildtype isolates. Our observations sugg

SUBMITTER: Eskier D 

PROVIDER: S-EPMC7560320 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature