Multi-time-point data preparation robustly reveals MCI and dementia risk factors.

ABSTRACT:

Introduction

Conflicting results on dementia risk factors have been reported across studies. We hypothesize that variation in data preparation methods may partially contribute to this issue.

Methods

We propose a comprehensive data preparation approach comparing individuals with stable diagnosis over time to those who progress to mild cognitive impairment (MCI)/dementia. This was compared to the often-used "baseline" analysis. Multivariate logistic regression was used to evaluate both methods.

Results

The results obtained from sensitivity analyses were consistent with those from our multi-time-point data preparation approach, exhibiting its robustness. Compared to analysis using only baseline data, the number of significant risk factors identified in progression analys

SUBMITTER: Kaur D 

PROVIDER: S-EPMC7560502 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature