The POOR Get POORer: A Hypothesis for the Pathogenesis of Ventilator-induced Lung Injury.

ABSTRACT: Protective ventilation strategies for the injured lung currently revolve around the use of low Vt, ostensibly to avoid volutrauma, together with positive end-expiratory pressure to increase the fraction of open lung and reduce atelectrauma. Protective ventilation is currently applied in a one-size-fits-all manner, and although this practical approach has reduced acute respiratory distress syndrome deaths, mortality is still high and improvements are at a standstill. Furthermore, how to minimize ventilator-induced lung injury (VILI) for any given lung remains controversial and poorly understood. Here we present a hypothesis of VILI pathogenesis that potentially serves as a basis upon which minimally injurious ventilation strategies might be developed. This hypothesis is based on evidence de

SUBMITTER: Gaver DP 

PROVIDER: S-EPMC7560804 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature