Isoniazid Preventive Therapy in Contacts of Multidrug-Resistant Tuberculosis.

ABSTRACT: Rationale: The World Health Organization recommends the use of isoniazid (INH) alone or in combination with rifapentine to treat latent tuberculosis infections. The recent rise of drug-resistant tuberculosis has complicated the choice of treatment regimen for latent tuberculosis infection.Objectives: To evaluate the effects of INH preventive therapy on the contacts of patients with multidrug-resistant tuberculosis.Methods: In a prospective cohort study conducted between September 2009 and August 2012, we identified 4,500 index patients with tuberculosis and 14,044 tuberculosis-exposed household contacts who we followed for 1 year for the occurrence of incident tuberculosis disease. Although Peruvian national guidelines specify that INH preventive therapy should be prov

SUBMITTER: Huang CC 

PROVIDER: S-EPMC7560814 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature