Serum metabolomics approach to monitor the changes in metabolite profiles following renal transplantation.

ABSTRACT: Systemic metabolic changes after renal transplantation reflect the key processes that are related to graft accommodation. In order to describe and better understand these changes, the ¹HNMR based metabolomics approach was used. The changes of 47 metabolites in the serum samples of 19 individuals were interpreted over time with respect to their levels prior to transplantation. Considering the specific repeated measures design of the experiments, data analysis was mainly focused on the multiple analyses of variance (ANOVA) methods such as ANOVA simultaneous component analysis and ANOVA-target projection. We also propose here the combined use of ANOVA and classification and regression trees (ANOVA-CART) under the assumption that a small set of metabolites the binary splits on which

SUBMITTER: Stanimirova I 

PROVIDER: S-EPMC7560840 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature