The structural role of osteocalcin in bone biomechanics and its alteration in Type-2 Diabetes.

ABSTRACT: This study presents an investigation into the role of Osteocalcin (OC) on bone biomechanics, with the results demonstrating that the protein's α-helix structures play a critical role in energy dissipation behavior in healthy conditions. In the first instance, α-helix structures have high affinity with the Hydroxyapatite (HAp) mineral surface and provide favorable conditions for adsorption of OC proteins onto the mineral surface. Using steered molecular dynamics simulation, several key energy dissipation mechanisms associated with α-helix structures were observed, which included stick-slip behavior, a sacrificial bond mechanism and a favorable binding feature provided by the Ca²⁺ motif on the OC protein. In the case of Type-2 Diabetes, this study demonstrated that possible glycat

SUBMITTER: Tavakol M 

PROVIDER: S-EPMC7560881 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature