The Delta-4 fibrosis score (D4FS): A novel fibrosis score in chronic hepatitis D.

ABSTRACT:

Background

Chronic Hepatitis D virus (HDV) infection results in the most severe form of viral hepatitis with a rapid progression to cirrhosis. However, non-invasive fibrosis tests that can accurately predict cirrhosis have not been adequately validated. We aimed to develop a clinically useful non-invasive score that can accurately detect cirrhosis.

Material and methods

Patients with chronic HDV diagnosed by liver histology or serum PCR were evaluated. Data regarding demographics, laboratory, imaging, vibration-controlled transient elastography (VCTE), and liver biopsy were collected. The total cohort was randomized into a training and validation cohort. The training cohort was used to develop a novel score, the Delta-4 fibrosis score (D4FS) which was then compared to other n

SUBMITTER: Da BL 

PROVIDER: S-EPMC7560973 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature