Association between matrix metalloproteinase-9 gene polymorphism and breast cancer in Brazilian women.

ABSTRACT:

Objective

This study aimed to determine the relationship between rs17576 (MMP-9) polymorphism and increased cancer risk in a Brazilian breast cancer cohort.

Methods

This study included 141 women (71 breast cancer patients and 70 controls without breast cancer) who donated 3 mL of their peripheral blood for genomic DNA extraction. This DNA was then genotyped using a real-time polymerase chain reaction.

Results

The AG (rs17576) genotype was identified in 26 (18.43%) participants in the case group and in 22 (15.60%) participants in the control group (p=0.274), while the GG genotype was identified in ten (7.09%) participants in the case group and in one (0.70%) participant in the control group (p<0.003 - OR (95% CI) 13.13 (1.73, 593.08). No significant difference in the i

SUBMITTER: Oliveira VA 

PROVIDER: S-EPMC7561070 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature