IL6-mediated HCoV-host interactome regulatory network and GO/Pathway enrichment analysis.

ABSTRACT: During these days of global emergency for the COVID-19 disease outbreak, there is an urgency to share reliable information able to help worldwide life scientists to get better insights and make sense of the large amount of data currently available. In this study we used the results presented in [1] to perform two different Systems Biology analyses on the HCoV-host interactome. In the first one, we reconstructed the interactome of the HCoV-host proteins, integrating it with highly reliable miRNA and drug interactions information. We then added the IL-6 gene, identified in recent publications [2] as heavily involved in the COVID-19 progression and, interestingly, we identified several interactions with the reconstructed interactome. In the second analysis, we performed a Gene Ontology and a

SUBMITTER: Politano G 

PROVIDER: S-EPMC7561109 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature