Patch dynamics modeling framework from pathogens' perspective: Unified and standardized approach for complicated epidemic systems.

ABSTRACT: Mathematical models are powerful tools to investigate, simulate, and evaluate potential interventions for infectious diseases dynamics. Much effort has focused on the Susceptible-Infected-Recovered (SIR)-type compartment models. These models consider host populations and measure change of each compartment. In this study, we propose an alternative patch dynamic modeling framework from pathogens' perspective. Each patch, the basic module of this modeling framework, has four standard mechanisms of pathogen population size change: birth (replication), death, inflow, and outflow. This framework naturally distinguishes between-host transmission process (inflow and outflow) and within-host infection process (replication) during the entire transmission-infection cycle. We demonstrate that the SIR-

SUBMITTER: Chen S 

PROVIDER: S-EPMC7561140 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature