An analysis of tissue-specific alternative splicing at the protein level.

ABSTRACT: The role of alternative splicing is one of the great unanswered questions in cellular biology. There is strong evidence for alternative splicing at the transcript level, and transcriptomics experiments show that many splice events are tissue specific. It has been suggested that alternative splicing evolved in order to remodel tissue-specific protein-protein networks. Here we investigated the evidence for tissue-specific splicing among splice isoforms detected in a large-scale proteomics analysis. Although the data supporting alternative splicing is limited at the protein level, clear patterns emerged among the small numbers of alternative splice events that we could detect in the proteomics data. More than a third of these splice events were tissue-specific and most were ancient: over 95%

SUBMITTER: Rodriguez JM 

PROVIDER: S-EPMC7561204 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature