Delayed global feedback in the genesis and stability of spatiotemporal excitation patterns in paced biological excitable media.

ABSTRACT: Biological excitable media, such as cardiac or neural cells and tissue, exhibit memory in which a change in the present excitation may affect the behaviors in the next excitation. For example, a change in calcium (Ca2+) concentration in a cell in the present excitation may affect the Ca2+ dynamics in the next excitation via bi-directional coupling between voltage and Ca2+, forming a delayed feedback loop. Since the Ca2+ dynamics inside the excitable cells are spatiotemporal while the membrane voltage is a global signal, the feedback loop is then a delayed global feedback (DGF) loop. In this study, we investigate the roles of DGF in the genesis and stability of spatiotemporal excitation patterns in periodically-paced excitable media using mathematical models with different levels of complex

SUBMITTER: Song Z 

PROVIDER: S-EPMC7561267 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature