Evidence for Tethering of Human Cytomegalovirus Genomes to Host Chromosomes.

ABSTRACT: Tethering of viral genomes to host chromosomes has been recognized in a variety of DNA and RNA viruses. It can occur during both the productive cycle and latent infection and may impact viral genomes in manifold ways including their protection, localization, transcription, replication, integration, and segregation. Tethering is typically accomplished by dedicated viral proteins that simultaneously associate with both the viral genome and cellular chromatin via nucleic acid, histone and/or non-histone protein interactions. Some of the most prominent tethering proteins have been identified in DNA viruses establishing sustained latent infections, including members of the papillomaviruses and herpesviruses. Herpesvirus particles have linear genomes that circularize in infected cell nuclei and

SUBMITTER: Mauch-Mucke K 

PROVIDER: S-EPMC7561393 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature