Urothelial toxicity of esketamine in the treatment of depression.

ABSTRACT:

Rationale

Ketamine is the first widely used substance with rapid-onset antidepressant action. However, there are uncertainties regarding its potential urothelial toxicity, particularly after repeated application. In the context of rising recreational ketamine use, severe side effects affecting the human urinary tract have been reported. It is assumed that ketamine interacts with bladder urothelial cells and induces apoptosis.

Objectives

This study aimed to assess whether single or repeated doses of esketamine used in an antidepressant indication are associated with urinary toxicity.

Methods

We included male and female inpatients with a current episode of depression and a diagnosis of recurrent depressive disorder, bipolar disorder or schizoaffective disorder according

SUBMITTER: Findeis H 

PROVIDER: S-EPMC7561544 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature