[¹⁸F]FDG PET/CT for evaluating early response to neoadjuvant chemotherapy in pediatric patients with sarcoma: a prospective single-center trial.

ABSTRACT:

Introduction

This is a prospective, single-center trial in pediatric patients with sarcoma aiming to evaluate [¹⁸F]FDG PET/CT as a tool for early response assessment to neoadjuvant chemotherapy (neo-CTX).

Methods

Bone or soft tissue sarcoma patients with (1) baseline [¹⁸F]FDG PET/CT within 4 weeks prior to the start of neo-CTX (PET1), (2) early interim [¹⁸F]FDG PET/CT (6 weeks after the start of neo-CTX (PET2), (3) evaluation of neo-CTX response by histology or MRI, and (4) definitive therapy after neo-CTX (surgery or radiation) were included. Semiquantitative PET parameters (SUVmax, SUVmean, SUVpeak, MTV and TLG) and their changes from PET1 to PET2 (ΔPET) were obtained. The primary endpoint was to evaluate the predictive value of PET1, PET2

SUBMITTER: Polverari G 

PROVIDER: S-EPMC7561652 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature