SARS-CoV-2 detection in the lower respiratory tract of invasively ventilated ARDS patients.

ABSTRACT:

Background

Data on SARS-CoV-2 load in lower respiratory tract (LRT) are scarce. Our objectives were to describe the viral shedding and the viral load in LRT and to determine their association with mortality in critically ill COVID-19 patients.

Methods

We conducted a binational study merging prospectively collected data from two COVID-19 reference centers in France and Switzerland. First, we described the viral shedding duration (i.e., time to negativity) in LRT samples. Second, we analyzed viral load in LRT samples. Third, we assessed the association between viral presence in LRT and mortality using mixed-effect logistic models for clustered data adjusting for the time between symptoms' onset and date of sampling.

Results

From March to May 2020, 267 LRT samples were p

SUBMITTER: Buetti N 

PROVIDER: S-EPMC7562762 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature