Electrophysiological Maturation of Cerebral Organoids Correlates with Dynamic Morphological and Cellular Development.

ABSTRACT: Cerebral organoids (COs) are rapidly accelerating the rate of translational neuroscience based on their potential to model complex features of the developing human brain. Several studies have examined the electrophysiological and neural network features of COs; however, no study has comprehensively investigated the developmental trajectory of electrophysiological properties in whole-brain COs and correlated these properties with developmentally linked morphological and cellular features. Here, we profiled the neuroelectrical activities of COs over the span of 5 months with a multi-electrode array platform and observed the emergence and maturation of several electrophysiologic properties, including rapid firing rates and network bursting events. To complement these analyses, we characterize

SUBMITTER: Fair SR 

PROVIDER: S-EPMC7562943 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature