The Role of HDL and HDL Mimetic Peptides as Potential Therapeutics for Alzheimer's Disease.

ABSTRACT: The role of high-density lipoproteins (HDL) in the cardiovascular system has been extensively studied and the cardioprotective effects of HDL are well established. As HDL particles are formed both in the systemic circulation and in the central nervous system, the role of HDL and its associated apolipoproteins in the brain has attracted much research interest in recent years. Alzheimer's disease (AD) is the most prevalent neurodegenerative disorder and the leading cause of dementia worldwide, for which there currently exists no approved disease modifying treatment. Multiple lines of evidence, including a number of large-scale human clinical studies, have shown a robust connection between HDL levels and AD. Low levels of HDL are associated with increased risk and severity of AD, whereas high

SUBMITTER: Chernick D 

PROVIDER: S-EPMC7563116 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature