Gene Expression Comparison between Sezary Syndrome and Lymphocytic-Variant Hypereosinophilic Syndrome Refines Biomarkers for Sezary Syndrome.

ABSTRACT: Sézary syndrome (SS), an aggressive cutaneous T-cell lymphoma (CTCL) with poor prognosis, is characterized by the clinical hallmarks of circulating malignant T cells, erythroderma and lymphadenopathy. However, highly variable clinical skin manifestations and similarities with benign mimickers can lead to significant diagnostic delay and inappropriate therapy that can lead to disease progression and mortality. SS has been the focus of numerous transcriptomic-profiling studies to identify sensitive and specific diagnostic and prognostic biomarkers. Benign inflammatory disease controls (e.g., psoriasis, atopic dermatitis) have served to identify chronic inflammatory phenotypes in gene expression profiles, but provide limited insight into the lymphoproliferative and oncogenic roles of abnormal

SUBMITTER: Moerman-Herzog A 

PROVIDER: S-EPMC7563155 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature