The Genomics and Metagenomics of Asthma Severity (GEMAS) Study: Rationale and Design.

ABSTRACT: Asthma exacerbations are a major contributor to the global disease burden, but no significant predictive biomarkers are known. The Genomics and Metagenomics of Asthma Severity (GEMAS) study aims to assess the role of genomics and the microbiome in severe asthma exacerbations. Here, we present the design of GEMAS and the characteristics of patients recruited from March 2018 to March 2020. Different biological samples and demographic and clinical variables were collected from asthma patients recruited by allergy and pulmonary medicine units in several hospitals from Spain. Cases and controls were defined by the presence/absence of severe asthma exacerbations in the past year (oral corticosteroid use, emergency room visits, and/or asthma-related hospitalizations). A total of 137 cases and 120

SUBMITTER: Perez-Garcia J 

PROVIDER: S-EPMC7563269 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature