Biocompatibility of α-Al2O3 Ceramic Substrates with Human Neural Precursor Cells.

ABSTRACT: Biocompatible materials-topography could be used for the construction of scaffolds allowing the three-dimensional (3D) organization of human stem cells into functional tissue-like structures with a defined architecture. Structural characterization of an alumina-based substrate was performed through XRD, Brunauer-Emmett-Teller (BET) analysis, scanning electron microscopy (SEM), and wettability measurements. Biocompatibility of the substrate was assessed by measuring the proliferation and differentiation of human neural precursor stem cells (NPCs). α-Al2O3 is a ceramic material with crystallite size of 40 nm; its surface consists of aggregates in the range of 8-22 μm which forms a rough surface in the microscale with 1-8 μm cavities. The non-calcined material has a surface area of 5.5 m2/gr

SUBMITTER: Asimakopoulou A 

PROVIDER: S-EPMC7563382 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature