Building towards Precision Oncology for Pancreatic Cancer: Real-World Challenges and Opportunities.

ABSTRACT: The advent of next-generation sequencing (NGS) has provided unprecedented insight into the molecular complexity of pancreatic ductal adenocarcinoma (PDAC). This has led to the emergence of biomarker-driven treatment paradigms that challenge empiric treatment approaches. However, the growth of sequencing technologies is outpacing the development of the infrastructure required to implement precision oncology as routine clinical practice. Addressing these logistical barriers is imperative to maximize the clinical impact of molecular profiling initiatives. In this review, we examine the evolution of precision oncology in PDAC, spanning from germline testing for cancer susceptibility genes to multi-omic tumor profiling. Furthermore, we highlight real-world challenges to delivering precision onc

SUBMITTER: Wang Y 

PROVIDER: S-EPMC7563487 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature