Behavioral and Psychological Symptoms of Dementia (BPSD): Clinical Characterization and Genetic Correlates in an Italian Alzheimer's Disease Cohort.

ABSTRACT:

Background

The occurrence of Behavioral and Psychological Symptoms of Dementia (BPSD) in Alzheimer's Disease (AD) patients hampers the clinical management and exacerbates the burden for caregivers. The definition of the clinical distribution of BPSD symptoms, and the extent to which symptoms are genetically determined, are still open to debate. Moreover, genetic factors that underline BPSD symptoms still need to be identified.

Purpose

To characterize our Italian AD cohort according to specific BPSD symptoms as well as to endophenotypes. To evaluate the associations between the considered BPSD traits and COMT, MTHFR, and APOE genetic variants.

Methods

AD patients (n = 362) underwent neuropsychological examination and genotyping. BPSD were as

SUBMITTER: Scassellati C 

PROVIDER: S-EPMC7563608 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature